insulin independence after fetal liver-derived cell suspension al¬lotransplantation in patients with type 1 diabetes: a pilot study
نویسندگان
چکیده
background: cell-based treatments are currently being actively received great attention among scientists and clinicians for a variety of diseases as well as diabetes .the aim of this study was to investigate the effect of allotransplantation of fetal liver-derived cell suspension in patients with type 1 diabetes. methods: patients with type 1 diabetes (n=16) aged 6-30 years-old were included in the study. fetal liver-derived cell suspension was transplanted by the means of intravenous injection patient. results: in most of patient, blood glucose levels gradually decreased within the first day of infusion. insulin independence occurred in 3 patients out of the 16 (18.7%) for 4 to 24 months. they showed increasing levels of serum c-peptide along with decreasing of levels of hba1c level. in other patients, no significant changes in parameters of diabetes control were observed. conclusion: findings of this study indicated that transplantation of fetal stem cells could, although not permanently, be an effective therapeutic intervention in patients with type 1 diabetes. to demonstrate effectiveness of stem-cell therapy for treatment of diabetes, more clinical trials with stricter inclusion criteria, modified protocols, and larger number of patients and are necessary as well as long periods of follow up.
منابع مشابه
the effect of fetal liver-derived cell suspension allotransplantation on patients with diabetes: first year of follow-up
stem cell-based therapies have recently opened up new horizons for treatment of various types of diseases including diabetes mellitus. however, long-term efficacy and safety of these novel modalities still remain a serious question. hereby, we aim to report the one-year follow-up results in the diabetic patients who underwent fetal liver-derived hematopoietic stem cell allotransplantation. fift...
متن کاملThe effect of fetal liver-derived cell suspension allotransplantation on patients with diabetes: first year of follow-up.
Stem cell-based therapies have recently opened up new horizons for treatment of various types of diseases including diabetes mellitus. However, long-term efficacy and safety of these novel modalities still remain a serious question. Hereby, we aim to report the one-year follow-up results in the diabetic patients who underwent fetal liver-derived hematopoietic stem cell allotransplantation. Fift...
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چکیده ندارد.
15 صفحه اولflowcytometric assessment of lymphocyte subsets in type-1 diabetic patients following allotransplantation of liver-derived fetal stem-cells
background: although the pathogenesis of diabetes type 1 (t1d) is not fully elucidated. different clusters of lymphocytes such as cd4+ and cd8+ t cells are involved in it. moreover, the mechanism of how stem-cell therapy results in significant therapeutic outcomes in diabetes remains obscure. in the current study, we aimed to analyze lymphocyte subsets in patients with t1d before and after trea...
متن کاملAlbuminuria in Diabetic Patients before and after Fetal Liver-Derived Cell Suspension Allotransplantion: a 24 Months Follow up Study
متن کامل
application of allotransplantation of fetal liver-derived stem-cells for treatment of type 1 diabetes: a single-arm, phase 3 clini¬cal trial
background: stem-cell technology has been advocated as a potentially curative option for treatment of both type 1 and type 2 diabetes. in the current study, we aimed to assess the effectiveness of allotransplantation of fetal liver-derived cells for treatment of patients with type 1 diabetes. methods: for the purpose of the current study, 72 patients with recently diagnosed type 1 dm were recru...
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عنوان ژورنال:
iranian journal of public healthجلد ۴۴، شماره ۲، صفحات ۲۷-۳۵
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